So Yakuza 6 is the story of the legendary Dragon of Dojima getting out of prison, finding out his adopted daughter is in danger and that he's a grandson, and charging solo through two different cities basically one-shotting everything in his way until answers manifest for him. It's a Yakuza game as told by the NPCs in Yakuza games.
The big one being in Chapter 4 (so like 20 minutes in on a WR pace) you have to load an autosave and hope a cab that has ~10% chance of spawning appears.